Low Blast Count Myeloid Disorders With Auer Rods

Low blast count myeloid disorders with Auer rods: a clinicopathologic analysis of 9 cases.

Auer rods are a hallmark of acute myeloid leukemia but occasionally are seen in myelodysplastic syndromes (MDSs) or chronic myelomonocytic leukemia, rarely in cases with fewer than 5% blasts. The significance of this finding is unclear. We report 9 cases of this unusual phenomenon. All patients had cytopenias, isolated to a single lineage in 4. Circulating blasts were present in 8 cases (rare t...

Auer rods in unusual sites: macrophage indigestion

The Difference in Initial Leukocyte Count, Bone Marrow Blast Cell Count and CD 34 Expression in Patients with Acute Myeloid Leukemia with and without NPM1 gene Mutation

Background: Mutation in NPM1 gene has been reported to be the most common genetic mutation in de novo acute myeloid leukemia (AML). AML with NPM1 gene mutation usually presents with higher initial leukocyte and blast cell counts and negative CD34 expression. We aimed to investigate the difference of initial leukocyte counts, bone marrow blast cell counts and expression of CD34 among patients wi...

Auer Rods Are Not Seen in Non-Neoplastic Cells

First I would like to thank Smeeta Gajendra for scrutinizing my article in her ‘Comment: In Response to “Auer Rod-Like Inclusions in Reactive Plasma Cells in a Case of Acute Myeloid Leukemia”’ published online and for bringing to light the missing reference of Sharma et al. [1], who reported a case of Auer rodlike inclusions in plasma cells in a case of therapy-related AML. I sincerely regret m...

Crystal structure of Auer rods in acute myeloblastic leukaemia (AMyL).

Ultrathin sections containing Auer rods from cases of acute myeloblastic leukaemia (AMyL) were tilted in the goniometer stage of the electron microscope and the resulting series of electronmicrographs analysed in an optical diffractometer illuminated by laser. The results showed that Auer rods of AMyL show a truly three dimensional crystal structure. Measurements from the optical diffraction pa...